Susobhan Sarkar Research interests or projects:Gliomas are the most common primary tumors that arise within the central nervous system in adults.
The most malignant form, glioblastoma multiforme (GBM), is resistant to current modalities of treatment.
The hallmark of gliomas is local invasion of single tumor cells to adjacent and distant brain structures.
Such invasiveness is mediated in part by the interaction of glioma cells with the extracellular matrix (ECM),
followed by degradation of matrix by tumor cell derived proteases, particularly the matrix metalloproteinases (MMPs) .
However, the specific interaction between glioma cells and particular ECM molecules, and how ECM may alter MMP
expression, are for the most part unclear. My research focuses on identifying molecular mechanisms of brain tumor invasion,
particularly identifying the role of ECM proteins, MMPs, cytokines, integrins and the signaling pathways involved with it.